Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA binding activity; WW domain binding activity; and magnesium ion binding activity. Involved in DNA metabolic process. Acts upstream of or within several processes, including DNA metabolic process; circulatory system development; and regulation of gene expression. Located in cytosol; endoplasmic reticulum; and nuclear replication fork. Part of oligosaccharyltransferase complex and protein-DNA complex. Is expressed in lens. Used to study Aicardi-Goutieres syndrome and cutaneous lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1).