Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Trex1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Trex1
  • participates in the following biological processes:
    • cellular response to interferon-beta ^[1]
  • performs the following molecular functions:
    • adenyl deoxyribonucleotide binding ^[2]
    • double-stranded DNA binding ^[1]
    • single-stranded DNA binding ^[2]
• Researchers have inferred, based on physical interactions, that the gene product of Trex1
  • performs the following molecular functions:
    • protein homodimerization activity ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Trex1:
  • performs the following molecular functions:
    • 3'-5' exonuclease activity
    • MutLalpha complex binding
    • MutSalpha complex binding

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Summary text based on GO annotations supported by structural data

• Trex1 encodes a protein or proteins that contain the following InterPro domains: Exonuclease, Ribonuclease H-like domain, indicating that the gene product:
  • performs the following molecular functions:
    • exonuclease activity
    • nucleic acid binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Trex1 indicates that it:
  • participates in the following biological processes:
    • DNA repair
    • response to DNA damage stimulus
  • performs the following molecular functions:
    • exonuclease activity
    • hydrolase activity
    • nuclease activity
  • is located in the following cellular components:
    • nucleus
• Trex1 has been associated with the Enzyme Commission numbers: 3.1.11.2, which implies that the gene product:
  • performs the following molecular functions:
    • exodeoxyribonuclease III activity

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References

1. Burckstummer T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol, 10:266-72. (PubMed:19158679)
2. de Silva U et al. (2007) The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. J Biol Chem, 282:10537-43. (PubMed:17293595)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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