Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Chkb. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Chkb
  • participates in the following biological processes:
    • CDP-choline pathway ^[1]
    • muscle organ development ^[1]
    • phosphatidylcholine biosynthetic process ^[1]
    • phosphorylation ^[1]
  • performs the following molecular functions:
    • choline kinase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Chkb:
  • participates in the following biological processes:
    • CDP-choline pathway
    • phosphatidylethanolamine biosynthetic process
  • performs the following molecular functions:
    • choline kinase activity
    • ethanolamine kinase activity
  • is located in the following cellular components:
    • cytoplasm

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Summary text based on GO annotations supported by structural data

• Chkb encodes a protein or proteins that contain the following InterPro domains: Choline/Ethanolamine kinase, Protein kinase-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • glycerophospholipid biosynthetic process
  • performs the following molecular functions:
    • kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Chkb indicates that it:
  • participates in the following biological processes:
    • lipid metabolic process
    • phospholipid biosynthetic process
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity

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References

1. Sher RB et al. (2006) A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem, 281:4938-48. (PubMed:16371353)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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