Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fga. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fga
  • is located in the following cellular components:
    • cell cortex ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fga
  • participates in the following biological processes:
    • blood coagulation ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fga:
  • participates in the following biological processes:
    • blood coagulation, common pathway
    • cell-matrix adhesion
    • cellular protein complex assembly
    • negative regulation of endothelial cell apoptotic process
    • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
    • platelet aggregation
    • positive regulation of ERK1 and ERK2 cascade
    • positive regulation of exocytosis
    • positive regulation of heterotypic cell-cell adhesion
    • positive regulation of peptide hormone secretion
    • positive regulation of protein secretion
    • positive regulation of vasoconstriction
    • protein polymerization
    • response to calcium ion
  • performs the following molecular functions:
    • cell adhesion molecule binding
    • receptor binding
    • structural molecule activity
  • is located in the following cellular components:
    • blood microparticle
    • cell surface
    • cytoplasm
    • external side of plasma membrane
    • extracellular space
    • extracellular vesicular exosome
    • fibrinogen complex
    • platelet alpha granule

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References

1. Ni H et al. (2000) Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest, 106:385-92. (PubMed:10930441)
2. Tolhurst G et al. (2005) Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling. Blood, 106:1644-51. (PubMed:15914557)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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