Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sucla2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Sucla2
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sucla2:
  • participates in the following biological processes:
    • metabolic process
    • succinate metabolic process
    • succinyl-CoA metabolic process
    • tricarboxylic acid cycle
  • performs the following molecular functions:
    • succinate-CoA ligase (ADP-forming) activity
    • succinate-CoA ligase activity
  • is located in the following cellular components:
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Sucla2 encodes a protein or proteins that contain the following InterPro domains: ATP-citrate lyase/succinyl-CoA ligase, ATP-grasp fold, ATP-grasp fold, subdomain 1, ATP-grasp fold, subdomain 2, ATP-grasp fold, succinyl-CoA synthetase-type, Succinyl-CoA synthetase, beta subunit, Succinyl-CoA synthetase, beta subunit, conserved site, Succinyl-CoA synthetase-like, indicating that the gene product:
  • performs the following molecular functions:
    • ATP binding
    • catalytic activity
    • metal ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sucla2 indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • ligase activity
    • nucleotide binding

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References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
2. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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