Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; osteoblast development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including embryonic morphogenesis; mammary gland development; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to several human genes including LRP5 (LDL receptor related protein 5).