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Gene Ontology Classifications
Symbol
Name
ID
Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lrp5. (This text reflects annotations as of Thursday, January 16, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 15, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. [provided by RefSeq, Nov 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Akhter MP et al. (2004) Bone biomechanical properties in LRP5 mutant mice. Bone, 35:162-9. (PubMed:15207752)
  2. Babij P et al. (2003) High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res, 18:960-74. (PubMed:12817748)
  3. Badders NM et al. (2009) The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One, 4:e6594. (PubMed:19672307)
  4. Dubrow SA et al. (2007) Gender specific LRP5 influences on trabecular bone structure and strength. J Musculoskelet Neuronal Interact, 7:166-73. (PubMed:17627087)
  5. Fujino T et al. (2003) Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A, 100:229-34. (PubMed:12509515)
  6. Gonzalez-Sancho JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol, 24:4757-68. (PubMed:15143170)
  7. Hay E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol Cell Biol, 29:953-64. (PubMed:19075000)
  8. Holmen SL et al. (2004) Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res, 19:2033-40. (PubMed:15537447)
  9. Iwaniec UT et al. (2007) PTH stimulates bone formation in mice deficient in Lrp5. J Bone Miner Res, 22:394-402. (PubMed:17147489)
  10. Kato M et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol, 157:303-14. (PubMed:11956231)
  11. Kelly OG et al. (2004) The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development, 131:2803-15. (PubMed:15142971)
  12. Kim MJ et al. (2008) SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J, 22:3785-94. (PubMed:18632848)
  13. Li ZG et al. (2008) Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone. Oncogene, 27:596-603. (PubMed:17700537)
  14. Lindvall C et al. (2006) The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem, 281:35081-7. (PubMed:16973609)
  15. Lindvall C et al. (2009) The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS One, 4:e5813. (PubMed:19503830)
  16. Lobov IB et al. (2005) WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature, 437:417-21. (PubMed:16163358)
  17. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
  18. Sawakami K et al. (2006) The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem, 281:23698-711. (PubMed:16790443)
  19. Wang Z et al. (2005) Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol, 25:5022-30. (PubMed:15923619)
  20. Xia CH et al. (2008) A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet, 17:1605-12. (PubMed:18263894)
  21. Xu Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell, 116:883-95. (PubMed:15035989)
  22. Yadav VK et al. (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell, 135:825-37. (PubMed:19041748)
  23. Ye X et al. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell, 139:285-98. (PubMed:19837032)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory