Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; embryonic morphogenesis; and tube morphogenesis. Localizes to mitochondrion. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Orthologous to human LRP5 (LDL receptor related protein 5).