Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bcat2. (This text reflects annotations as of Thursday, January 16, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 10, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Bcat2
  • performs the following molecular functions:
    • branched-chain-amino-acid transaminase activity ^[5]
  • is located in the following cellular components:
    • mitochondrion ^{[2, 3, 5]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Bcat2
  • participates in the following biological processes:
    • branched-chain amino acid catabolic process ^[5]
    • branched-chain amino acid metabolic process ^[1]
    • isoleucine catabolic process ^[4]
    • isoleucine metabolic process ^[5]
    • leucine metabolic process ^{[4, 5]}
    • regulation of hormone levels ^[4]
    • valine metabolic process ^{[4, 5]}

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bcat2:
  • participates in the following biological processes:
    • branched-chain amino acid catabolic process
    • isoleucine catabolic process
    • leucine biosynthetic process
  • performs the following molecular functions:
    • branched-chain-amino-acid transaminase activity
  • is located in the following cellular components:
    • cytoplasm
    • mitochondrion
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Bcat2 encodes a protein or proteins that contain the following InterPro domains: Aminotransferase, class IV, Aminotransferase, class IV, conserved site, Branched-chain amino acid aminotransferase II, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • catalytic activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bcat2 indicates that it:
  • participates in the following biological processes:
    • branched-chain amino acid biosynthetic process
    • cellular amino acid biosynthetic process
  • performs the following molecular functions:
    • transaminase activity
    • transferase activity
• Bcat2 has been associated with the Enzyme Commission numbers: 2.6.1.42, which implies that the gene product:
  • performs the following molecular functions:
    • L-isoleucine transaminase activity
    • L-leucine transaminase activity
    • L-valine transaminase activity

---

References

1. Lang CH et al. (2010) Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase. J Nutr, 140:932-8. (PubMed:20237068)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
4. She P et al. (2007) Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab, 6:181-94. (PubMed:17767905)
5. Wu JY et al. (2004) ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. J Clin Invest, 113:434-40. (PubMed:14755340)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---