Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables arachidonate 12(S)-lipoxygenase activity; arachidonate 8(R)-lipoxygenase activity; and linoleate 9S-lipoxygenase activity. Involved in ceramide biosynthetic process; establishment of skin barrier; and unsaturated fatty acid metabolic process. Located in perinuclear region of cytoplasm. Is expressed in cerebral cortex; gut epithelium; nasal cavity epithelium; and skin. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 2. Orthologous to human ALOX12B (arachidonate 12-lipoxygenase, 12R type).