Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits I-SMAD binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including animal organ development; negative regulation of osteoblast differentiation; and regulation of chondrocyte development. Localizes to centrosome and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb bud; and sensory organ. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in colorectal cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2).