Automated description from the Alliance of Genome Resources
Exhibits I-SMAD binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including animal organ development; cell population proliferation; and negative regulation of osteoblast differentiation. Localizes to the centrosome and nucleus. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2).