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Gene Ontology Classifications
Symbol
Name
ID
Axin2
axin2
MGI:1270862

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GO curators for mouse genes have assigned the following annotations to the gene product of Axin2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Aulehla A et al. (2003) Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell, 4:395-406. (PubMed:12636920)
  2. Behrens J et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science, 280:596-9. (PubMed:9554852)
  3. Brauburger K et al. (2014) Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-beta-catenin signalling. FEBS J, 281:787-801. (PubMed:24251807)
  4. Chassot AA et al. (2011) RSPO1/beta-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS One, 6:e25641. (PubMed:21991325)
  5. Dao DY et al. (2010) Axin2 regulates chondrocyte maturation and axial skeletal development. J Orthop Res, 28:89-95. (PubMed:19623616)
  6. Hadjihannas MV et al. (2012) Cell cycle control of Wnt/beta-catenin signalling by conductin/axin2 through CDC20. EMBO Rep, 13:347-54. (PubMed:22322943)
  7. Hadjihannas MV et al. (2010) Conductin/axin2 and Wnt signalling regulates centrosome cohesion. EMBO Rep, 11:317-24. (PubMed:20300119)
  8. Klaus A et al. (2012) Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells. Proc Natl Acad Sci U S A, 109:10921-6. (PubMed:22711842)
  9. Liu W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J, 25:1646-58. (PubMed:16601693)
  10. Yu HM et al. (2005) The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development, 132:1995-2005. (PubMed:15790973)
  11. Zeng YA et al. (2010) Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell, 6:568-77. (PubMed:20569694)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory