Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc6a2. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc6a2
  • participates in the following biological processes:
    • neurotransmitter transport ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc6a2
  • participates in the following biological processes:
    • response to pain ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc6a2:
  • participates in the following biological processes:
    • monoamine transport
    • norepinephrine transport
    • transmembrane transport
  • performs the following molecular functions:
    • alpha-tubulin binding
    • beta-tubulin binding
    • monoamine transmembrane transporter activity
    • norepinephrine transmembrane transporter activity
  • is located in the following cellular components:
    • cell surface
    • membrane raft
    • neuron projection
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Slc6a2 encodes a protein or proteins that contain the following InterPro domains: Sodium:neurotransmitter symporter, Sodium:neurotransmitter symporter, noradrenaline, indicating that the gene product:
  • performs the following molecular functions:
    • neurotransmitter:sodium symporter activity
  • is located in the following cellular components:
    • integral component of membrane
    • integral component of plasma membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc6a2 indicates that it:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • symporter activity
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. Jasmin L et al. (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline. Proc Natl Acad Sci U S A, 99:1029-34. (PubMed:11805341)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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