Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Naga. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Naga:
  • participates in the following biological processes:
    • carbohydrate catabolic process
    • glycolipid catabolic process
    • glycoside catabolic process
    • glycosylceramide catabolic process
    • oligosaccharide metabolic process
  • performs the following molecular functions:
    • alpha-galactosidase activity
    • alpha-N-acetylgalactosaminidase activity
    • protein homodimerization activity
  • is located in the following cellular components:
    • cytoplasm

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Summary text based on GO annotations supported by structural data

• Naga encodes a protein or proteins that contain the following InterPro domains: Aldolase-type TIM barrel, Glycoside hydrolase, clan GH-D, Glycoside hydrolase, family 27, Glycoside hydrolase, superfamily, Glycosyl hydrolase, family 13, all-beta, indicating that the gene product:
  • participates in the following biological processes:
    • carbohydrate metabolic process
  • performs the following molecular functions:
    • catalytic activity
    • hydrolase activity, hydrolyzing O-glycosyl compounds

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Naga indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity
    • hydrolase activity, acting on glycosyl bonds
  • is located in the following cellular components:
    • lysosome

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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