Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dpagt1. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 26, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Dpagt1
  • performs the following molecular functions:
    • UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Dpagt1:
  • participates in the following biological processes:
    • dolichol biosynthetic process
    • dolichol metabolic process
    • dolichol-linked oligosaccharide biosynthetic process
    • protein N-linked glycosylation
    • UDP-N-acetylglucosamine metabolic process
  • performs the following molecular functions:
    • UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
    • UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
  • is located in the following cellular components:
    • intracellular membrane-bounded organelle
    • membrane

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Summary text based on GO annotations supported by structural data

• Dpagt1 encodes a protein or proteins that contain the following InterPro domains: Glycosyl transferase, family 4, indicating that the gene product:
  • performs the following molecular functions:
    • phospho-N-acetylmuramoyl-pentapeptide-transferase activity
  • is located in the following cellular components:
    • integral component of membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dpagt1 indicates that it:
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring glycosyl groups
  • is located in the following cellular components:
    • endoplasmic reticulum
    • integral component of membrane

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References

1. Rajput B et al. (1992) Mouse UDP-GlcNAc: dolichyl-phosphate N-acetylglucosaminephosphotransferase. Molecular cloning of the cDNA, generation of anti-peptide antibodies and chromosomal localization. Biochem J, 285:985-92. (PubMed:1323278)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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