Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rgs2. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rgs2
  • participates in the following biological processes:
    • brown fat cell differentiation ^[5]
  • is located in the following cellular components:
    • internal side of plasma membrane ^[1]
• The gene product of Rgs2 has been shown to bind to the gene products of Ppp1r9b. ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Rgs2
  • participates in the following biological processes:
    • negative regulation of cardiac muscle hypertrophy ^[2]
    • negative regulation of G-protein coupled receptor protein signaling pathway ^[2]
    • negative regulation of MAP kinase activity ^[2]
    • negative regulation of phospholipase activity ^[2]
    • positive regulation of cardiac muscle contraction ^{[1, 2]}
    • regulation of adrenergic receptor signaling pathway ^[1]
    • relaxation of cardiac muscle ^[2]
    • relaxation of vascular smooth muscle ^[3]
  • is located in the following cellular components:
    • cytosol ^[2]
    • plasma membrane ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rgs2:
  • participates in the following biological processes:
    • negative regulation of G-protein coupled receptor protein signaling pathway
    • positive regulation of GTPase activity
    • positive regulation of microtubule polymerization
  • performs the following molecular functions:
    • beta-tubulin binding
    • GTPase activator activity
  • is located in the following cellular components:
    • cytoplasm
    • internal side of plasma membrane
    • neuron projection
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Rgs2 encodes a protein or proteins that contain the following InterPro domains: Regulator of G protein signalling, Regulator of G protein signalling superfamily, Regulator of G-protein signaling, domain 1, indicating that the gene product:
  • participates in the following biological processes:
    • termination of G-protein coupled receptor signaling pathway

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rgs2 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • negative regulation of signal transduction
    • regulation of translation
  • is located in the following cellular components:
    • membrane

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References

1. Chakir K et al. (2011) RGS2 is a primary terminator of beta(2)-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol, 50:1000-7. (PubMed:21291891)
2. Takimoto E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest, 119:408-20. (PubMed:19127022)
3. Tang M et al. (2003) Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med, 9:1506-12. (PubMed:14608379)
4. Wang X et al. (2007) Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors. EMBO J, 26:2768-76. (PubMed:17464283)
5. Wu Y et al. (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab, 295:E205-15. (PubMed:18492766)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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