Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ogdh. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ogdh
  • participates in the following biological processes:
    • oxidation-reduction process ^[2]
  • performs the following molecular functions:
    • oxoglutarate dehydrogenase (NAD+) activity ^[2]
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ogdh:
  • participates in the following biological processes:
    • 2-oxoglutarate metabolic process
    • NADH metabolic process
    • succinyl-CoA metabolic process
    • tricarboxylic acid cycle
  • performs the following molecular functions:
    • chaperone binding
    • heat shock protein binding
    • oxoglutarate dehydrogenase (succinyl-transferring) activity
  • is located in the following cellular components:
    • mitochondrion
    • oxoglutarate dehydrogenase complex

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Summary text based on GO annotations supported by structural data

• Ogdh encodes a protein or proteins that contain the following InterPro domains: 2-oxoglutarate dehydrogenase, E1 component, Dehydrogenase, E1 component, Transketolase-like, pyrimidine-binding domain, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    • thiamine pyrophosphate binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ogdh indicates that it:
  • participates in the following biological processes:
    • glycolysis
  • performs the following molecular functions:
    • oxidoreductase activity

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References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
2. Oktay Y et al. (2007) Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin. J Biol Chem, 282:11750-6. (PubMed:17322295)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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