Automated description from the Alliance of Genome Resources
Exhibits water channel activity. Involved in cellular response to water deprivation; metanephric collecting duct development; and renal water transport. Localizes to the apical plasma membrane; lumenal side of membrane; and recycling endosome. Used to study nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus. Is expressed in inner ear; metanephros; vestibulo-cochlear ganglion; and vestibulocochlear nerve cochlear component. Orthologous to human AQP2 (aquaporin 2).