Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hcn1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hcn1
  • performs the following molecular functions:
    • cAMP binding ^[2]
  • is located in the following cellular components:
    • axon ^[1]
    • dendrite ^[3]
• The gene product of Hcn1 has been shown to bind to the gene products of Pex5l. ^[3] Researchers have inferred, based on physical interactions, that the gene product of Hcn1
  • performs the following molecular functions:
    • identical protein binding ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Hcn1
  • participates in the following biological processes:
    • apical protein localization ^[3]
    • cellular response to cAMP ^[2]
    • potassium ion transmembrane transport ^[2]
    • regulation of ion transmembrane transport ^[2]
    • retinal cone cell development ^[4]
  • performs the following molecular functions:
    • intracellular cAMP activated cation channel activity ^[2]
    • voltage-gated potassium channel activity ^[2]
  • is located in the following cellular components:
    • integral component of plasma membrane ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Hcn1:
  • participates in the following biological processes:
    • cellular response to cAMP
    • potassium ion transmembrane transport
    • regulation of membrane potential
    • sodium ion transmembrane transport
  • performs the following molecular functions:
    • voltage-gated potassium channel activity
    • voltage-gated sodium channel activity
  • is located in the following cellular components:
    • integral component of plasma membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Hcn1 encodes a protein or proteins that contain the following InterPro domains: Cyclic nucleotide-binding domain, Cyclic nucleotide-binding, conserved site, Cyclic nucleotide-binding-like, Ion transport domain, Ion transport N-terminal, Potassium channel, voltage-dependent, EAG/ELK/ERG, RmlC-like jelly roll fold, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • potassium ion transport
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hcn1 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • potassium ion transport
    • sodium ion transport
    • transport
  • performs the following molecular functions:
    • nucleotide binding
    • potassium channel activity
    • sodium channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. Ango F et al. (2004) Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. Cell, 119:257-72. (PubMed:15479642)
2. Lolicato M et al. (2011) Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem, 286:44811-20. (PubMed:22006928)
3. Santoro B et al. (2004) Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction. J Neurosci, 24:10750-62. (PubMed:15564593)
4. Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol, 2011:391384. (PubMed:21052544)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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