Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables metallodipeptidase activity and metalloendopeptidase activity. Involved in several processes, including germinal center formation; lymphocyte differentiation; and proteolysis. Acts upstream of or within negative regulation of neuron projection development; regulation of axon regeneration; and regulation of neuron migration. Located in cytoplasm and membrane. Is active in plasma membrane. Is expressed in several structures, including foregut-midgut junction; heart; lung; nervous system; and retina. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).