Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Htr2b. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Htr2b
  • participates in the following biological processes:
    • cellular response to temperature stimulus ^[5]
    • G-protein coupled receptor internalization ^[5]
    • response to drug ^[5]
    • serotonin receptor signaling pathway ^[5]
  • performs the following molecular functions:
    • drug binding ^[5]
    • serotonin binding ^[5]
    • serotonin receptor activity ^[5]
  • is located in the following cellular components:
    • cytoplasm ^[5]
    • plasma membrane ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Htr2b
  • participates in the following biological processes:
    • cardiac muscle hypertrophy ^[4]
    • embryonic morphogenesis ^[3]
    • ERK1 and ERK2 cascade ^{[6, 7]}
    • heart development ^[8]
    • heart morphogenesis ^[3]
    • negative regulation of apoptotic process ^[3]
    • neural crest cell differentiation ^[3]
    • neural crest cell migration ^[3]
    • positive regulation of cell division ^[6]
    • positive regulation of cytokine secretion ^[4]
    • positive regulation of endothelial cell proliferation ^[1]
    • protein kinase C-activating G-protein coupled receptor signaling pathway ^[5]
    • regulation of behavior ^[2]
  • performs the following molecular functions:
    • Ras GTPase activator activity ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Htr2b:
  • participates in the following biological processes:
    • calcium ion transmembrane transport
    • calcium-mediated signaling
    • cellular response to calcium ion
    • cGMP biosynthetic process
    • ERK1 and ERK2 cascade
    • G-protein coupled receptor internalization
    • G-protein coupled receptor signaling pathway
    • intestine smooth muscle contraction
    • negative regulation of autophagy
    • negative regulation of cell death
    • phosphatidylinositol 3-kinase cascade
    • phosphatidylinositol biosynthetic process
    • phosphorylation
    • positive regulation of cell proliferation
    • positive regulation of cytokine production
    • positive regulation of endothelial cell proliferation
    • positive regulation of MAP kinase activity
    • positive regulation of nitric-oxide synthase activity
    • protein kinase C signaling cascade
    • regulation of behavior
    • release of sequestered calcium ion into cytosol
    • response to drug
    • serotonin receptor signaling pathway
    • vasoconstriction
  • performs the following molecular functions:
    • calcium channel activity
    • drug binding
    • G-protein alpha-subunit binding
    • phosphatidylinositol phospholipase C activity
    • serotonin binding
    • serotonin receptor activity
  • is located in the following cellular components:
    • cytoplasm
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Htr2b encodes a protein or proteins that contain the following InterPro domains: 5-Hydroxytryptamine 2B receptor, 5-Hydroxytryptamine receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Htr2b indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Asada M et al. (2009) Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Neoplasia, 11:408-17. (PubMed:19308295)
2. Bevilacqua L et al. (2010) A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature, 468:1061-6. (PubMed:21179162)
3. Choi DS et al. (1997) 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Development, 124:1745-55. (PubMed:9165122)
4. Jaffre F et al. (2009) Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ Res, 104:113-23. (PubMed:19023134)
5. Janoshazi A et al. (2007) Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors. Mol Pharmacol, 71:1463-74. (PubMed:17325130)
6. Launay JM et al. (1996) Ras involvement in signal transduction by the serotonin 5-HT2B receptor. J Biol Chem, 271:3141-7. (PubMed:8621713)
7. Li B et al. (2010) Serotonin increases ERK(1/2) phosphorylation in astrocytes by stimulation of 5-HT(2B) and 5-HT(2C) receptors. Neurochem Int, null:null. (PubMed:20450948)
8. Nebigil CG et al. (2000) Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci U S A, 97:9508-13. (PubMed:10944220)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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