Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription factor binding activity; protein heterodimerization activity; and transcription regulator activator activity. Involved in several processes, including blood vessel development; intrinsic apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within ER overload response; negative regulation of fat cell differentiation; and sensory perception of sound. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3).