Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mnx1. (This text reflects annotations as of Tuesday, July 8, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mnx1
  • participates in the following biological processes:
    • dorsal/ventral neural tube patterning ^[]
  • is located in the following cellular components:
    • nucleus ^{[, ]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mnx1
  • participates in the following biological processes:
    • cell morphogenesis involved in neuron differentiation ^[]
    • central nervous system neuron differentiation ^[]
    • diaphragm development ^[]
    • endocrine pancreas development ^[]
    • motor neuron axon guidance ^[]
    • nerve development ^[]
    • neuron differentiation ^[]
    • neuron migration ^[]
    • neuron projection morphogenesis ^[]
    • pancreas development ^[]
    • post-embryonic development ^[]
    • respiratory system development ^[]
    • spinal cord motor neuron cell fate specification ^[]

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Summary text based on GO annotations supported by structural data

• Mnx1 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-templated
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mnx1 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-templated
    • transcription, DNA-templated
  • performs the following molecular functions:
    • DNA binding

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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