Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mnx1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mnx1
  • participates in the following biological processes:
    • dorsal/ventral neural tube patterning ^[2]
  • is located in the following cellular components:
    • nucleus ^{[3, 5]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mnx1
  • participates in the following biological processes:
    • cell morphogenesis involved in neuron differentiation ^[1]
    • central nervous system neuron differentiation ^[1]
    • diaphragm development ^[1]
    • endocrine pancreas development ^[4]
    • motor neuron axon guidance ^[1]
    • nerve development ^[6]
    • neuron differentiation ^[6]
    • neuron migration ^[1]
    • neuron projection morphogenesis ^[1]
    • pancreas development ^[4]
    • post-embryonic development ^[1]
    • respiratory system development ^[1]
    • spinal cord motor neuron cell fate specification ^[1]

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Summary text based on GO annotations supported by structural data

• Mnx1 encodes a protein or proteins that contain the following InterPro domains: Homeobox, conserved site, Homeodomain, Homeodomain, metazoa, Homeodomain-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-templated
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mnx1 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-templated
    • transcription, DNA-templated
  • performs the following molecular functions:
    • DNA binding

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References

1. Arber S et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity [see comments] Neuron, 23:659-74. (PubMed:10482234)
2. Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol, 321:27-39. (PubMed:18590716)
3. Kelly CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol, 11:e1001538. (PubMed:23610558)
4. Li H et al. (1999) Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet, 23:67-70. (PubMed:10471501)
5. Winseck AK et al. (2006) An in vivo analysis of Schwann cell programmed cell death in embryonic mice: the role of axons, glial growth factor, and the pro-apoptotic gene Bax. Eur J Neurosci, 24:2105-17. (PubMed:17042795)
6. Yang X et al. (2001) Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron, 30:399-410. (PubMed:11395002)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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