Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adcy9. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Adcy9
  • participates in the following biological processes:
    • cAMP biosynthetic process ^[1]

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Summary text based on GO annotations supported by structural data

• Adcy9 encodes a protein or proteins that contain the following InterPro domains: Adenylyl cyclase class-3/4/guanylyl cyclase, Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • cyclic nucleotide biosynthetic process
    • intracellular signal transduction
  • performs the following molecular functions:
    • phosphorus-oxygen lyase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adcy9 indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • lyase activity
    • metal ion binding
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Paterson JM et al. (1995) Control of a novel adenylyl cyclase by calcineurin. Biochem Biophys Res Commun, 214:1000-8. (PubMed:7575502)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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