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Gene Ontology Classifications
Symbol
Name
ID
Traf6
TNF receptor-associated factor 6
MGI:108072

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Automated description from the Alliance of Genome Resources

Exhibits ubiquitin protein ligase activity. Involved in several processes, including chordate embryonic development; myeloid leukocyte differentiation; and positive regulation of cytokine biosynthetic process. Localizes to several cellular components, including the CD40 receptor complex; cytoplasmic side of plasma membrane; and lipid droplet. Used to study hypohidrotic ectodermal dysplasia. Is expressed in several structures, including future brain; lower jaw; mandibular process; reproductive system; and sensory organ. Orthologous to human TRAF6 (TNF receptor associated factor 6).



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Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement

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Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory