Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin protein ligase activity. Involved in several processes, including bone resorption; cytokine-mediated signaling pathway; and positive regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; lipopolysaccharide-mediated signaling pathway; and regulation of gene expression. Located in cytoplasmic side of plasma membrane; cytosol; and lipid droplet. Part of CD40 receptor complex. Is expressed in several structures, including aorta-gonad-mesonephros; future brain; lower jaw; mandibular process; and sensory organ. Used to study hypohidrotic ectodermal dysplasia. Orthologous to human TRAF6 (TNF receptor associated factor 6).