Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Wnt10a. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of July 22, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Wnt10a
  • participates in the following biological processes:
    • neural crest cell differentiation ^[1]
    • positive regulation of gene expression ^[1]
    • regulation of odontogenesis of dentin-containing tooth ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Wnt10a:
  • participates in the following biological processes:
    • anterior/posterior pattern specification
    • axis specification
    • canonical Wnt receptor signaling pathway
    • epidermis morphogenesis
    • female gonad development
    • hair follicle development
    • hair follicle morphogenesis
    • negative regulation of transcription from RNA polymerase II promoter
    • odontogenesis
    • positive regulation of transcription from RNA polymerase II promoter
    • sebaceous gland development
    • skin development
    • tongue development
  • performs the following molecular functions:
    • G-protein coupled receptor binding
  • is located in the following cellular components:
    • extracellular space
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Wnt10a encodes a protein or proteins that contain the following InterPro domains: Wnt, Wnt protein, conserved site, Wnt-10 protein, indicating that the gene product:
  • participates in the following biological processes:
    • multicellular organismal development
    • Wnt receptor signaling pathway
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Wnt10a indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • Wnt receptor signaling pathway
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. Yamashiro T et al. (2007) Wnt10a regulates dentin sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis. Differentiation, 75:452-462. (PubMed:17286598)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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