Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adm. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Adm
  • participates in the following biological processes:
    • branching involved in labyrinthine layer morphogenesis ^[3]
    • developmental growth ^[3]
    • heart development ^{[1, 2, 3]}
    • negative regulation of vascular permeability ^[2]
    • neural tube closure ^[3]
    • positive regulation of angiogenesis ^[2]
    • positive regulation of cell proliferation ^[1]
    • positive regulation of vasculogenesis ^[2]
    • spongiotrophoblast layer development ^[3]
    • vascular smooth muscle cell development ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Adm:
  • participates in the following biological processes:
    • androgen metabolic process
    • calcium ion homeostasis
    • cAMP biosynthetic process
    • elevation of cytosolic calcium ion concentration
    • G-protein coupled receptor internalization
    • hormone secretion
    • negative regulation of cell proliferation
    • negative regulation of vasoconstriction
    • neuron projection regeneration
    • positive regulation of apoptotic process
    • positive regulation of cAMP biosynthetic process
    • positive regulation of heart rate
    • positive regulation of vasodilation
    • receptor internalization
    • regulation of the force of heart contraction
    • response to lipopolysaccharide
    • response to stress
    • response to wounding
    • vasculogenesis
  • performs the following molecular functions:
    • adrenomedullin receptor binding
  • is located in the following cellular components:
    • cytoplasm
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Adm encodes a protein or proteins that contain the following InterPro domains: Adrenomedullin, Procalcitonin/adrenomedullin, indicating that the gene product:
  • performs the following molecular functions:
    • hormone activity
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adm indicates that it:
  • performs the following molecular functions:
    • hormone activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Dackor RT et al. (2006) Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Mol Cell Biol, 26:2511-8. (PubMed:16537897)
2. Ichikawa-Shindo Y et al. (2008) The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest, 118:29-39. (PubMed:18097473)
3. Li M et al. (2006) Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. J Clin Invest, 116:2653-62. (PubMed:16981008)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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