Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Scn10a. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Scn10a
  • participates in the following biological processes:
    • regulation of ion transmembrane transport ^[2]
    • sodium ion transmembrane transport ^[2]
    • sodium ion transport ^[2]
  • performs the following molecular functions:
    • voltage-gated sodium channel activity ^[2]
  • is located in the following cellular components:
    • axon ^[2]
    • C-fiber ^[2]
    • plasma membrane ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Scn10a
  • participates in the following biological processes:
    • cardiac conduction ^[1]
    • regulation of atrial cardiac muscle cell membrane depolarization ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Scn10a:
  • participates in the following biological processes:
    • AV node cell to bundle of His cell communication
    • bundle of His cell to Purkinje myocyte communication
    • membrane depolarization during action potential
    • neuronal action potential
    • regulation of atrial cardiac muscle cell membrane depolarization
    • regulation of cardiac muscle contraction
    • regulation of heart rate
    • regulation of ion transmembrane transport
    • sensory perception of pain
    • sodium ion transmembrane transport
    • sodium ion transport
  • performs the following molecular functions:
    • voltage-gated sodium channel activity
  • is located in the following cellular components:
    • clathrin complex
    • extracellular vesicular exosome
    • integral component of membrane
    • voltage-gated sodium channel complex

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Summary text based on GO annotations supported by structural data

• Scn10a encodes a protein or proteins that contain the following InterPro domains: Ion transport domain, IQ motif, EF-hand binding site, Sodium ion transport-associated, Voltage gated sodium channel, alpha subunit, Voltage-dependent potassium channel, four helix bundle domain, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Scn10a indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • sodium channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • membrane

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References

1. Chambers JC et al. (2010) Genetic variation in SCN10A influences cardiac conduction. Nat Genet, 42:149-52. (PubMed:20062061)
2. Rush AM et al. (2005) Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci, 22:39-49. (PubMed:16029194)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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