Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd36. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cd36
  • participates in the following biological processes:
    • cell surface receptor signaling pathway ^[4]
    • cellular response to lipoteichoic acid ^[2]
    • low-density lipoprotein particle mediated signaling ^[4]
    • phagocytosis, recognition ^[10]
    • positive regulation of peptidyl-tyrosine phosphorylation ^[4]
    • positive regulation of phagocytosis, engulfment ^[10]
  • performs the following molecular functions:
    • Gram-negative bacterial cell surface binding ^[10]
    • Gram-positive bacterial cell surface binding ^[10]
    • high-density lipoprotein particle binding ^[1]
  • is located in the following cellular components:
    • external side of plasma membrane ^{[2, 10]}
    • Golgi apparatus ^[7]
    • membrane raft ^[7]
    • plasma membrane ^{[7, 8]}
• The gene product of Cd36 has been shown to bind to the gene products of Thbs2. ^[9]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cd36
  • participates in the following biological processes:
    • apoptotic cell clearance ^[5]
    • cellular response to bacterial lipopeptide ^[2]
    • cellular response to hydroperoxide ^[4]
    • cellular response to lipopolysaccharide ^[10]
    • cellular response to lipoteichoic acid ^{[2, 10]}
    • cholesterol transport ^[3]
    • defense response to Gram-positive bacterium ^{[2, 10]}
    • lipid storage ^[6]
    • lipoprotein transport ^[6]
    • low-density lipoprotein particle clearance ^[6]
    • negative regulation of gene expression ^[4]
    • negative regulation of growth of symbiont in host ^{[2, 10]}
    • negative regulation of transcription factor import into nucleus ^[4]
    • negative regulation of transcription from RNA polymerase II promoter ^[4]
    • pattern recognition receptor signaling pathway ^[10]
    • plasma lipoprotein particle clearance ^[3]
    • positive regulation of blood coagulation ^[4]
    • positive regulation of blood microparticle formation ^[4]
    • positive regulation of cholesterol storage ^[3]
    • positive regulation of I-kappaB kinase/NF-kappaB cascade ^[10]
    • positive regulation of interleukin-12 production ^[10]
    • positive regulation of interleukin-6 production ^[10]
    • positive regulation of macrophage cytokine production ^[10]
    • positive regulation of macrophage derived foam cell differentiation ^{[3, 6]}
    • positive regulation of MAPK cascade ^[2]
    • positive regulation of phagocytosis, engulfment ^[10]
    • positive regulation of reactive oxygen species metabolic process ^[4]
    • positive regulation of tumor necrosis factor production ^{[2, 10]}
    • regulation of removal of superoxide radicals ^[4]
  • performs the following molecular functions:
    • lipoteichoic acid receptor activity ^[10]
    • low-density lipoprotein particle binding ^{[3, 6]}
    • low-density lipoprotein receptor activity ^[6]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Cd36
  • participates in the following biological processes:
    • regulation of transcription from RNA polymerase II promoter in response to oxidative stress ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cd36:
  • participates in the following biological processes:
    • cGMP-mediated signaling
    • fatty acid metabolic process
    • fatty acid oxidation
    • fatty acid transport
    • lipid storage
    • lipoprotein transport
    • long-chain fatty acid import
    • long-chain fatty acid metabolic process
    • long-chain fatty acid transport
    • low-density lipoprotein particle clearance
    • negative regulation of angiogenesis
    • negative regulation of systemic arterial blood pressure
    • nitric oxide mediated signal transduction
    • plasma membrane long-chain fatty acid transport
    • positive regulation of cell-matrix adhesion
    • positive regulation of cytokine secretion
    • positive regulation of macrophage derived foam cell differentiation
    • response to mechanical stimulus
    • triglyceride metabolic process
  • performs the following molecular functions:
    • lipid binding
    • lipoprotein particle binding
    • low-density lipoprotein particle binding
    • low-density lipoprotein receptor activity
    • oleic acid binding
    • thrombospondin receptor activity
    • transforming growth factor beta binding
  • is located in the following cellular components:
    • apical part of cell
    • caveola
    • cell surface
    • endoplasmic reticulum
    • intracellular
    • intracellular membrane-bounded organelle
    • mitochondrion
    • plasma membrane
    • protein complex
    • sarcolemma

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Summary text based on GO annotations supported by structural data

• Cd36 encodes a protein or proteins that contain the following InterPro domains: Adhesion molecule CD36, CD36 antigen, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cd36 indicates that it:
  • participates in the following biological processes:
    • cell adhesion
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. de Beer MC et al. (2004) ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36. J Lipid Res, 45:706-15. (PubMed:14729860)
2. Hoebe K et al. (2005) CD36 is a sensor of diacylglycerides. Nature, 433:523-7. (PubMed:15690042)
3. Kunjathoor VV et al. (2002) Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem, 277:49982-8. (PubMed:12376530)
4. Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest, 120:3996-4006. (PubMed:20978343)
5. Monks J et al. (2005) Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ, 12:107-14. (PubMed:15647754)
6. Podrez EA et al. (2000) Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest, 105:1095-108. (PubMed:10772654)
7. Pohl J et al. (2005) FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell, 16:24-31. (PubMed:15496455)
8. Schwenk RW et al. (2010) Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes. Diabetologia, 53:2209-19. (PubMed:20582536)
9. Simantov R et al. (2005) The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein. Matrix Biol, 24:27-34. (PubMed:15748999)
10. Stuart LM et al. (2005) Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol, 170:477-85. (PubMed:16061696)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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