Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ndufv1. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 26, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ndufv1
  • is located in the following cellular components:
    • mitochondrial inner membrane ^[1]
    • mitochondrion ^{[2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ndufv1:
  • is located in the following cellular components:
    • mitochondrial respiratory chain complex I

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Summary text based on GO annotations supported by structural data

• Ndufv1 encodes a protein or proteins that contain the following InterPro domains: NADH ubiquinone oxidoreductase, F subunit, NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding, NADH:ubiquinone oxidoreductase, 51kDa subunit, NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site, Soluble ligand binding domain, indicating that the gene product:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • 4 iron, 4 sulfur cluster binding
    • FMN binding
    • NAD binding
    • NADH dehydrogenase (ubiquinone) activity
    • oxidoreductase activity, acting on NAD(P)H

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ndufv1 indicates that it:
  • participates in the following biological processes:
    • electron transport chain
    • oxidation-reduction process
    • transport
  • performs the following molecular functions:
    • 4 iron, 4 sulfur cluster binding
    • iron-sulfur cluster binding
    • metal ion binding
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane
    • respiratory chain
• Ndufv1 has been associated with the Enzyme Commission numbers: 1.6.5.3, 1.6.99.3, which implies that the gene product:
  • performs the following molecular functions:
    • NADH dehydrogenase (ubiquinone) activity
    • NADH dehydrogenase activity

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References

1. Da Cruz S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem, 278:41566-71. (PubMed:12865426)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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