Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sema5a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Sema5a
  • participates in the following biological processes:
    • axon guidance ^[2]
    • signal transduction ^[2]
  • performs the following molecular functions:
    • axon guidance receptor activity ^[2]
  • is located in the following cellular components:
    • integral to membrane ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Sema5a
  • participates in the following biological processes:
    • axon guidance ^[2]
    • branching morphogenesis of a tube ^[1]
    • patterning of blood vessels ^[1]

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Summary text based on GO annotations supported by structural data

• Sema5a encodes a protein or proteins that contain the following InterPro domains: Plexin, Plexin-like fold, Plexin/semaphorin/integrin, Semaphorin/CD100 antigen, Thrombospondin, type 1 repeat, WD40/YVTN repeat-like-containing domain, indicating that the gene product:
  • participates in the following biological processes:
    • multicellular organismal development
  • performs the following molecular functions:
    • receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sema5a indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • nervous system development
  • is located in the following cellular components:
    • membrane

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References

1. Fiore R et al. (2005) Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system. Mol Cell Biol, 25:2310-9. (PubMed:15743826)
2. Oster SF et al. (2003) Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. Development, 130:775-84. (PubMed:12506007)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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