Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ATP binding activity; ATP-activated inward rectifier potassium channel activity; and ankyrin binding activity. Involved in negative regulation of insulin secretion and potassium ion import across plasma membrane. Acts upstream of or within several processes, including CAMKK-AMPK signaling cascade; determination of adult lifespan; and response to ischemia. Located in T-tubule. Part of inward rectifying potassium channel. Is active in plasma membrane. Is expressed in several structures, including brain; cardiovascular system; gut; skeletal muscle tissue; and testis. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11).