Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcnj11. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Kcnj11
  • participates in the following biological processes:
    • potassium ion import ^[1]
    • regulation of ion transmembrane transport ^[1]
  • performs the following molecular functions:
    • ATP binding ^[2]
    • ATP-activated inward rectifier potassium channel activity ^[1]
  • is located in the following cellular components:
    • ATP-sensitive potassium channel complex ^[1]
    • plasma membrane ^[4]
    • T-tubule ^[3]
• The gene product of Kcnj11 has been shown to bind to the gene products of Ank2. ^[3] Researchers have inferred, based on physical interactions, that the gene product of Kcnj11
  • performs the following molecular functions:
    • ankyrin binding ^[3]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Kcnj11
  • performs the following molecular functions:
    • potassium ion binding ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kcnj11:
  • participates in the following biological processes:
    • glucose metabolic process
    • negative regulation of insulin secretion
    • neurological system process
    • potassium ion transmembrane transport
    • potassium ion transport
    • regulation of insulin secretion
    • regulation of membrane potential
    • response to ATP
    • response to drug
  • performs the following molecular functions:
    • ankyrin binding
    • ATP-activated inward rectifier potassium channel activity
    • heat shock protein binding
    • ion channel binding
    • protein C-terminus binding
    • voltage-gated potassium channel activity
  • is located in the following cellular components:
    • ATP-sensitive potassium channel complex
    • endoplasmic reticulum
    • intracellular membrane-bounded organelle
    • mitochondrion
    • plasma membrane
    • sarcolemma
    • T-tubule
    • voltage-gated potassium channel complex

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Summary text based on GO annotations supported by structural data

• Kcnj11 encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin E-set, Potassium channel, inwardly rectifying, Kir, Potassium channel, inwardly rectifying, Kir, cytoplasmic, Potassium channel, inwardly rectifying, Kir6.2, indicating that the gene product:
  • performs the following molecular functions:
    • inward rectifier potassium channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcnj11 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Inagaki N et al. (1996) A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Neuron, 16:1011-7. (PubMed:8630239)
2. John SA et al. (2003) Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2. J Physiol, 552:23-34. (PubMed:12860923)
3. Li J et al. (2010) Ankyrin-B regulates Kir6.2 membrane expression and function in heart. J Biol Chem, 285:28723-30. (PubMed:20610380)
4. Morrissey A et al. (2005) Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart. Pediatr Res, 58:185-92. (PubMed:16085792)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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