Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd38. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cd38
  • participates in the following biological processes:
    • positive regulation of B cell proliferation ^[1]
  • is located in the following cellular components:
    • cell surface ^{[3, 4]}
    • membrane ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cd38
  • participates in the following biological processes:
    • metabolic process ^[2]
  • performs the following molecular functions:
    • hydrolase activity, acting on glycosyl bonds ^[2]
    • phosphorus-oxygen lyase activity ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cd38:
  • participates in the following biological processes:
    • B cell receptor signaling pathway
    • elevation of cytosolic calcium ion concentration
    • long term synaptic depression
    • negative regulation of apoptotic process
    • negative regulation of bone resorption
    • negative regulation of transcription, DNA-dependent
    • positive regulation of B cell proliferation
    • positive regulation of cell growth
    • positive regulation of insulin secretion
    • positive regulation of transcription, DNA-dependent
    • positive regulation of vasoconstriction
    • response to drug
    • response to hormone stimulus
    • response to hydroperoxide
    • response to hypoxia
  • performs the following molecular functions:
    • NAD+ nucleosidase activity
  • is located in the following cellular components:
    • intracellular membrane-bounded organelle
    • nucleus
    • plasma membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cd38 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • integral to membrane

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References

1. Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med, 183:1707-18. (PubMed:8666928)
2. Ceni C et al. (2003) CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain. Biochem J, 370:175-83. (PubMed:12403647)
3. Schenten D et al. (2006) M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood, 107:4849-56. (PubMed:16493007)
4. Yoder MC et al. (1997) Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity, 7:335-44. (PubMed:9324354)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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