Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables alpha-catenin binding activity; beta-catenin binding activity; and cadherin binding activity. Involved in forebrain development; positive regulation of neurogenesis; and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; nervous system development; and positive regulation of polarized epithelial cell differentiation. Located in several cellular components, including basolateral plasma membrane; clathrin-coated pit; and early endosome. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and thymus. Orthologous to human NUMB (NUMB endocytic adaptor protein).