Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tinf2. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tinf2
  • participates in the following biological processes:
    • negative regulation of telomere maintenance ^[1]
  • is located in the following cellular components:
    • chromosome, telomeric region ^[1]
• The gene product of Tinf2 has been shown to bind to the gene products of Terf1. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tinf2:
  • participates in the following biological processes:
    • negative regulation of epithelial cell proliferation
    • negative regulation of protein ADP-ribosylation
    • negative regulation of telomere maintenance via telomerase
    • positive regulation of telomere maintenance
    • protein localization to chromosome
    • protein localization to chromosome, telomeric region
    • telomere assembly
    • telomere maintenance via telomere lengthening
  • performs the following molecular functions:
    • telomeric DNA binding
  • is located in the following cellular components:
    • chromosome, telomeric region
    • nuclear telomere cap complex
    • perinucleolar chromocenter

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tinf2 indicates that it:
  • is located in the following cellular components:
    • chromosome
    • nucleus

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References

1. Kim S et al. (2003) Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2. Genomics, 81:422-32. (PubMed:12676566)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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