Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables cholesterol transfer activity; phosphatidylethanolamine transfer activity; and triglyceride transfer activity. Involved in circadian rhythm. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein transport; and low-density lipoprotein particle remodeling. Located in endoplasmic reticulum. Is expressed in several structures, including gut; liver; placenta; septum transversum hepatic component; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein).