Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mttp. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mttp
  • participates in the following biological processes:
    • lipid metabolic process ^[1]
    • lipid transport ^[1]
    • lipoprotein transport ^[3]
    • protein lipidation ^[1]
    • triglyceride metabolic process ^[1]
  • performs the following molecular functions:
    • lipid transporter activity ^[1]
  • is located in the following cellular components:
    • endoplasmic reticulum ^[3]
    • Golgi apparatus ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mttp
  • participates in the following biological processes:
    • cholesterol homeostasis ^[2]
    • lipoprotein metabolic process ^[2]
    • lipoprotein transport ^[2]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mttp:
  • participates in the following biological processes:
    • lipid transport
    • lipoprotein metabolic process
  • performs the following molecular functions:
    • apolipoprotein binding
    • lipid transporter activity
    • protein heterodimerization activity
  • is located in the following cellular components:
    • basolateral plasma membrane
    • brush border membrane
    • Golgi apparatus
    • membrane-bounded vesicle
    • microvillus membrane
    • rough endoplasmic reticulum

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mttp indicates that it:
  • participates in the following biological processes:
    • cholesterol metabolic process
    • steroid metabolic process
    • transport
  • performs the following molecular functions:
    • lipid binding

---

References

1. Kulinski A et al. (2002) Microsomal Triacylglycerol Transfer Protein Is Required for Lumenal Accretion of Triacylglycerol Not Associated with ApoB, as Well as for ApoB Lipidation. J Biol Chem, 277:31516-25. (PubMed:12072432)
2. Leung GK et al. (2000) A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion. J Biol Chem, 275:7515-20. (PubMed:10713055)
3. Mohler PJ et al. (2007) Identification of a novel isoform of microsomal triglyceride transfer protein. J Biol Chem, 282:26981-8. (PubMed:17635917)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---