Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Epcam. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Epcam
  • is located in the following cellular components:
    • cell surface ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Epcam:
  • participates in the following biological processes:
    • positive regulation of cell proliferation
  • is located in the following cellular components:
    • apical plasma membrane
    • basolateral plasma membrane
    • integral to membrane
    • lateral plasma membrane
    • plasma membrane
    • tight junction

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Epcam indicates that it:
  • is located in the following cellular components:
    • cell junction
    • membrane

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References

1. Kont V et al. (2008) Modulation of Aire regulates the expression of tissue-restricted antigens. Mol Immunol, 45:25-33. (PubMed:17599412)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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