Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gyk. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gyk
  • participates in the following biological processes:
    • phosphorylation ^[1]
  • performs the following molecular functions:
    • glycerol kinase activity ^[1]
  • is located in the following cellular components:
    • mitochondrion ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Gyk
  • participates in the following biological processes:
    • glycerol metabolic process ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gyk:
  • participates in the following biological processes:
    • glycerol metabolic process
    • glycerol-3-phosphate biosynthetic process
    • response to ethanol
    • triglyceride metabolic process
  • performs the following molecular functions:
    • glycerol kinase activity
    • histone binding
  • is located in the following cellular components:
    • mitochondrion
    • nucleus

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Summary text based on GO annotations supported by structural data

• Gyk encodes a protein or proteins that contain the following InterPro domains: Carbohydrate kinase, FGGY, C-terminal, Carbohydrate kinase, FGGY, conserved site, Carbohydrate kinase, FGGY, N-terminal, Glycerol kinase, indicating that the gene product:
  • participates in the following biological processes:
    • carbohydrate metabolic process
    • glycerol-3-phosphate metabolic process
  • performs the following molecular functions:
    • phosphotransferase activity, alcohol group as acceptor

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gyk indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity
  • is located in the following cellular components:
    • cytoplasm
    • membrane
    • mitochondrial outer membrane

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References

1. Kuwada N et al. (2005) Gene therapy for murine glycerol kinase deficiency: Importance of murine ortholog. Biochem Biophys Res Commun, 335:247-255. (PubMed:16105550)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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