Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables chromatin binding activity. Involved in heterochromatin formation; kidney development; and maintenance of DNA methylation. Acts upstream of or within several processes, including DNA methylation; cellular response to leukemia inhibitory factor; and negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and pericentric heterochromatin. Is expressed in several structures, including gut; hippocampus; neural retina; reproductive system; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific).