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Gene Ontology Classifications
Symbol
Name
ID
Anxa5
annexin A5
MGI:106008

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Anxa5. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med, 206:2987-3000. (PubMed:19934022)
  2. Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood, 117:6120-31. (PubMed:21508411)
  3. Kathiresan T et al. (2009) A protein interaction network for the large conductance Ca2+-activated K+ channel in the mouse cochlea. Mol Cell Proteomics, null:null. (PubMed:19423573)
  4. Kawamura H et al. (2006) P2X7 receptors regulate NKT cells in autoimmune hepatitis. J Immunol, 176:2152-60. (PubMed:16455971)
  5. Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol, 177:6650-9. (PubMed:17082577)
  6. Knowlton MN et al. (2003) The zebrafish band 4.1 member Mir is involved in cell movements associated with gastrulation. Dev Biol, 264:407-29. (PubMed:14651927)
  7. Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest, 120:3996-4006. (PubMed:20978343)
  8. Maeda A et al. (2009) Transcription factor GATA-3 is essential for lens development. Dev Dyn, 238:2280-2291. (PubMed:19623612)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory