Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to glucagon stimulus; and positive regulation of insulin secretion. Acts upstream of or within cardiac muscle cell proliferation; mesoderm formation; and sarcomere organization. Located in several cellular components, including centrosome; multivesicular body; and sperm connecting piece. Part of cAMP-dependent protein kinase complex. Is active in cytosol and glutamatergic synapse. Is expressed in several structures, including brain; branchial arch; ganglia; sensory organ; and tooth. Used to study Carney complex; acrodysostosis; primary pigmented nodular adrenocortical disease; and thyroid gland follicular carcinoma. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha).