Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription factor binding activity; MDM2/MDM4 family protein binding activity; and enzyme inhibitor activity. Involved in several processes, including negative regulation of lymphocyte proliferation; negative regulation of protein localization to nucleolus; and positive regulation of apoptotic process. Acts upstream of or within several processes, including keratinocyte proliferation; negative regulation of mammary gland epithelial cell proliferation; and oncogene-induced cell senescence. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including bone marrow; central nervous system; eye; hand epithelium; and male reproductive gland or organ. Used to study high grade glioma; malignant peripheral nerve sheath tumor; melanoma (multiple); and pancreatic carcinoma (multiple). Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A).
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