Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nnat. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of the BLCAP gene, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nnat
  • is located in the following cellular components:
    • cytoplasm ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nnat
  • participates in the following biological processes:
    • positive regulation of insulin secretion ^[1]
    • regulation of protein localization ^[1]
    • response to glucose stimulus ^[1]

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Summary text based on GO annotations supported by structural data

• Nnat encodes a protein or proteins that contain the following InterPro domains: Neuronatin, indicating that the gene product:
  • participates in the following biological processes:
    • brain development

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nnat indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development

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References

1. Chu K et al. (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes, 54:1064-73. (PubMed:15793245)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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