Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables WW domain binding activity and ligand-gated sodium channel activity. Contributes to sodium channel activity. Involved in intracellular sodium ion homeostasis and sodium ion import across plasma membrane. Acts upstream of or within several processes, including artery smooth muscle contraction; cellular response to aldosterone; and mucus secretion. Located in external side of plasma membrane. Part of sodium channel complex. Is expressed in several structures, including aorta; endocrine gland; genitourinary system; lung; and stomach. Used to study Liddle syndrome and autosomal recessive pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta).