Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ambn. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ambn
  • participates in the following biological processes:
    • cell adhesion ^[1]
    • cell proliferation ^[1]
  • performs the following molecular functions:
    • growth factor activity ^[1]

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Summary text based on GO annotations supported by structural data

• Ambn encodes a protein or proteins that contain the following InterPro domains: Ameloblastin precursor, indicating that the gene product:
  • participates in the following biological processes:
    • odontogenesis of dentin-containing tooth
  • performs the following molecular functions:
    • structural constituent of tooth enamel

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ambn indicates that it:
  • participates in the following biological processes:
    • biomineral tissue development
  • is located in the following cellular components:
    • extracellular region

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References

1. Zeichner-David M et al. (2006) Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells. Eur J Oral Sci, 114 Suppl 1:244-53; discussion 254-6, 381-. (PubMed:16674693)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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