Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable C-C chemokine binding activity; C-C chemokine receptor activity; and phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of monocyte chemotaxis; and positive regulation of osteoclast differentiation. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif chemokine receptor 1).