Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription repressor activity. Involved in cellular response to lipopolysaccharide and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including inner ear development; mechanosensory behavior; and regulation of cell fate specification. Predicted to be located in nuclear body and nuclear matrix. Predicted to be part of transcription repressor complex. Is expressed in several structures, including aorta-gonad-mesonephros; cranial ganglion; gut epithelium; hemolymphoid system; and sensory organ. Used to study severe congenital neutropenia. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).