Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cish. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cish
  • participates in the following biological processes:
    • protein kinase C-activating G-protein coupled receptor signaling pathway ^[1]
  • is located in the following cellular components:
    • plasma membrane ^[1]

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Summary text based on GO annotations supported by structural data

• Cish encodes a protein or proteins that contain the following InterPro domains: SH2 domain, SOCS protein, C-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cish indicates that it:
  • participates in the following biological processes:
    • negative regulation of signal transduction
    • regulation of growth

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References

1. Chen S et al. (2003) Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells. Int Immunol, 15:403-9. (PubMed:12618484)
2. Eyckerman S et al. (2001) Design and application of a cytokine-receptor-based interaction trap. Nat Cell Biol, 3:1114-9. (PubMed:11781573)
3. Montoye T et al. (2005) A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach. Blood, 105:4264-71. (PubMed:15644415)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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