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Gene Ontology Classifications
Symbol
Name
ID
E2f4
E2F transcription factor 4
MGI:103012

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of E2f4. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Chang WY et al. (2004) The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification. J Biol Chem, 279:51343-53. (PubMed:15448153)
  2. Danielian PS et al. (2007) E2f4 is required for normal development of the airway epithelium. Dev Biol, 305:564-76. (PubMed:17383628)
  3. Giangrande PH et al. (2004) A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Genes Dev, 18:2941-51. (PubMed:15574595)
  4. Humbert PO et al. (2000) E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell, 6:281-91. (PubMed:10983976)
  5. Izumi M et al. (2000) Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an ets-related transcription factor, and Sp1 Biochim Biophys Acta, 1492:341-52. (PubMed:11004506)
  6. Rempel RE et al. (2000) Loss of E2F4 activity leads to abnormal development of multiple cellular lineages Mol Cell, 6:293-306. (PubMed:10983977)
  7. Wang D et al. (2000) E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo. Mol Cell Biol, 20:3417-24. (PubMed:10779331)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory