Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lhx4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lhx4
  • is located in the following cellular components:
    • intracellular ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lhx4
  • participates in the following biological processes:
    • negative regulation of apoptotic process ^[2]
    • organ morphogenesis ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Lhx4
  • participates in the following biological processes:
    • medial motor column neuron differentiation based on interactions with Lhx3 ^[3]
    • motor neuron axon guidance based on interactions with Lhx3 ^[3]
    • placenta development based on interactions with Lhx3 ^[4]

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Summary text based on GO annotations supported by structural data

• Lhx4 encodes a protein or proteins that contain the following InterPro domains: Homeobox, conserved site, Homeodomain, Homeodomain-like, Zinc finger, LIM-type, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
    • zinc ion binding
  • is located in the following cellular components:
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lhx4 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding
  • is located in the following cellular components:
    • nucleus

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References

1. Arber S et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity [see comments] Neuron, 23:659-74. (PubMed:10482234)
2. Raetzman LT et al. (2002) Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development, 129:4229-39. (PubMed:12183375)
3. Sharma K et al. (1998) LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell, 95:817-28. (PubMed:9865699)
4. Tian G et al. (2008) Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Dev Dyn, 237:1517-25. (PubMed:18425848)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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