Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd79a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cd79a
  • participates in the following biological processes:
    • B cell receptor signaling pathway ^{[5, 8]}
  • is located in the following cellular components:
    • B cell receptor complex ^{[5, 8]}
    • external side of plasma membrane ^[5]
    • membrane raft ^{[1, 2]}
    • multivesicular body ^[4]
• The gene product of Cd79a has been shown to bind to the gene products of Cd79b, Syk. ^{[5, 8]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cd79a
  • participates in the following biological processes:
    • B cell activation ^[6]
    • B cell differentiation ^{[3, 7]}
    • B cell proliferation ^[6]

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Summary text based on GO annotations supported by structural data

• Cd79a encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin subtype, Immunoglobulin-like, Immunoglobulin-like fold, Phosphorylated immunoreceptor signaling ITAM, indicating that the gene product:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
  • performs the following molecular functions:
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cd79a indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Cheng PC et al. (1999) A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med, 190:1549-60. (PubMed:10587346)
2. Cheng PC et al. (2001) Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling. J Immunol, 166:3693-701. (PubMed:11238609)
3. Kraus M et al. (2001) Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail. J Exp Med, 194:455-69. (PubMed:11514602)
4. Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med, 195:461-72. (PubMed:11854359)
5. Matsuuchi L et al. (1992) The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Proc Natl Acad Sci U S A, 89:3404-8. (PubMed:1373499)
6. Patterson HC et al. (2006) The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. Immunity, 25:55-65. (PubMed:16860757)
7. Pelanda R et al. (2002) B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. J Immunol, 169:865-72. (PubMed:12097390)
8. Richards JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk prottein-tyrosine kinase. J Biol Chem, 271:6458-66. (PubMed:8626447)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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