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Gene Ontology Classifications
Symbol
Name
ID
Cd79a
CD79A antigen (immunoglobulin-associated alpha)
MGI:101774

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd79a. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Cheng PC et al. (1999) A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med, 190:1549-60. (PubMed:10587346)
  2. Cheng PC et al. (2001) Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling. J Immunol, 166:3693-701. (PubMed:11238609)
  3. Kraus M et al. (2001) Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail. J Exp Med, 194:455-69. (PubMed:11514602)
  4. Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med, 195:461-72. (PubMed:11854359)
  5. Matsuuchi L et al. (1992) The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Proc Natl Acad Sci U S A, 89:3404-8. (PubMed:1373499)
  6. Patterson HC et al. (2006) The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. Immunity, 25:55-65. (PubMed:16860757)
  7. Pelanda R et al. (2002) B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. J Immunol, 169:865-72. (PubMed:12097390)
  8. Richards JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk prottein-tyrosine kinase. J Biol Chem, 271:6458-66. (PubMed:8626447)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory