Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Elk3. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Elk3
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent ^[1]
  • performs the following molecular functions:
    • DNA binding ^[1]
    • sequence-specific DNA binding transcription factor activity ^[1]
  • is located in the following cellular components:
    • nucleus ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Elk3
  • participates in the following biological processes:
    • angiogenesis ^[1]
    • wound healing ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Elk3:
  • participates in the following biological processes:
    • negative regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • purine-rich negative regulatory element binding
    • transcription corepressor activity
  • is located in the following cellular components:
    • intracellular membrane-bounded organelle
    • mitochondrion
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Elk3 encodes a protein or proteins that contain the following InterPro domains: Ets, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • performs the following molecular functions:
    • sequence-specific DNA binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Elk3 indicates that it:
  • participates in the following biological processes:
    • transcription, DNA-dependent

---

References

1. Zheng H et al. (2003) The transcription factor Net regulates the angiogenic switch. Genes Dev, 17:2283-97. (PubMed:12975317)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---