The basic unit of heredity; a portion of DNA that (usually) codes for a protein product.
See also Central Dogma.
In MGI, "gene" may be used to refer to any of the following:
- A locus in the cytoplasmic or nuclear genome characterized by an altered phenotype or by an effect on an inserted reporter gene, such as a gene trap or enhancer trap.
- A locus in the cytoplasmic or nuclear genome that is necessary and sufficient to express the complete complement of functional products derived from a unit of transcription.
- A locus in the cytoplasmic or nuclear genome identified by hybridization to a nucleic acid segment derived from a non-mouse species, where the segment used as probe represents some portion of a functional unit of transcription in the cytoplasmic or nuclear genome of the non-mouse species.
- An exon-encoding segment of the germ-line nuclear genome located within a region that undergoes somatic rearrangement.
- A locus in the cytoplasmic or nuclear genome that is within an intron of (but not, itself, an exon of) a unit of transcription, which gives rise to a functional product upon transcript processing of the host unit. For example, Rnu73a and Rnu73b are contained in introns of Rsp3a.