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Color Atlas of Neoplastic and Non-neoplastic Lesions in Aging Mice C. H. Frith and J. M. Ward

LIST OF FIGURES

1. The Potential Histopathogenesis of Cancer in Mice

2. Epicardial Mineralization (H & E)

3. Epicardial Mineralization (von Kossa)

4. Epicardial Mineralization (Alizarin Red)

5. Myocardial Mineralization

6. Atrial Thrombosis - Left Atrium

7. Atrial Thrombosis - Cartilaginous Metaplasia

8. Medial Vascular Hypertrophy

9. Medial Mineralization - Thalamus

10. Coronary Atherosclerosis

11. Coronary Atherosclerosis

12. Coronary Polyarteritis

13. Ovarian Angiectasis

14. Hepatic Angiectasis

15. Hemangioma - Uterus

16. Hemangiosarcoma - Liver

17. Pulmonary Metastasis - Hepatic Hemangiosarcoma

18. Female and Male Submaxillary Salivary Glands

19. Lobular Atrophy - Salivary Gland

20. Salivary Gland Myoepithelioma

21. Myoepithelioma - Keratin

22. Myoepithelioma Intermediate Filaments - Vimentin

23. Adenoma - Serous Cells - Submaxillary Salivary Gland

24. Adenoma - Mucous Cells - Submaxillary Salivary Gland

25. Parotid Adenocarcinoma

26. Electron Micrograph - Male Submaxillary Gland - Granules

27. Electron Micrograph - Female Submaxillary Gland

28. Electron Micrograph - Myoepithelioma - Fibrils

29. Electron Micrograph - Myoepithelioma - Desmosomes

30. Pancreatic Acinar Atrophy with Fatty Replacement

31. Pancreatic Islet Cell Hyperplasia

32. Immunoperoxidase - Insulin - Islet Hyperplasia

33. Immunoperoxidase - Somatostatin - Islet Hyperplasia

34. Immunoperoxidase - Glucagon - Islet Hyperplasia

35. Islet Cell Adenoma

36. Islet Cell Carcinoma

37. Islet Cell Carcinoma - Somatostatin

38. Gastric Glandular Hyperplasia

39. Gastric Adenoma - Glandular Stomach

40. Gastric Adenocarcinoma

41. Squamous Hyperplasia - Forestomach

42. Squamous Cell Papilloma - Forestomach

43. Squamous Cell Papilloma - Forestomach

44. Squamous Cell Carcinoma - Forestomach

45. Pulmonary Metastasis - Gastric Squamous Cell Carcinoma

46. Intestinal Amyloidosis (H & E)

47. Intestinal Amyloidosis (Thioflavin T)

48. Intestinal Intussusception

49. Pinworms - Colon

50. Small Adenoma (Polyp) - Small Intestine

51. Large Adenoma (Polyp) - Large Intestine

52. Intestinal Adenocarcinoma

53. Intestinal Leiomyosarcoma

54. Granulopoietic Hyperplasia - Liver

55. Erythropoietic Hyperplasia - Liver

56. Fatty Metamorphosis - Liver (H & E)

57. Fatty Metamorphosis - Liver

58. Lipid Storage Disease - Liver

59. Hemosiderosis - Kupffer Cells - Liver (H & E)

60. Hemosiderosis - Kupffer Cells - Liver (Prussian Blue)

61. Ceroid Pigment - Liver

62. Coagulative Necrosis - Liver

63. Giant Cells - Mouse Hepatitis Virus Infection - Liver

64. Tyzzer's Disease - Liver (Warthin-Starry Stain)

65. Amyloidosis - Liver (H & E)

66. Amyloidosis - Liver (Congo Red)

67. Karyomegaly and Cytomegaly - Liver

68. Intranuclear Inclusion - Hepatocyte

69. Intracytoplasmic Inclusions - Hepatocytes

70. Bile Duct Hyperplasia - Liver

71. Oval Cell Hyperplasia - Liver

72. Cholangiofibrosis (Adenofibrosis) - Liver

73. Cholangitis

74. Hepatocellular Eosinophilic Cell Focus

75. Hepatocellular Basophilic Cell Focus

76. Hepatocellular Vacuolated Cell Focus

77. Hepatocellular Clear Cell Focus

78. Basophilic Hepatocellular Adenoma (Right Side)

79. Eosinophilic Hepatocellular Adenoma (Right Side)

80. Vacuolated Hepatocellular Adenoma

81. Hepatocellular Adenoma Immunoreactive for Alpha Fetoprotein

82. Hepatocellular Carcinoma within Adenoma

83. Trabecular Hepatocellular Carcinoma

84. Well-Differentiated Hepatocellular Carcinoma

85. Moderately Well-Differentiated Hepatocellular Carcinoma

86. Poorly Differentiated Hepatocellular Carcinoma

87. Pulmonary Metastasis - Hepatocellular Carcinoma

88. Hepatoblastoma

89. Hepatoblastoma - Keratin Stain

90. Well Differentiated Cholangiocarcinoma

91. Poorly Differentiated Cholangiocarcinoma

92. Hepatocellular Adenocarcinoma

93. Cholangiohepatocellular (Mixed) Carcinoma

94. Gall Stones

95. Eosinophilic Crystals - Gall Bladder

96. Gall Bladder Papilloma

97. Gall Bladder Carcinoma

98. Eosinophilic Crystals - Pulmonary Alveolar Macrophages

99. Chronic Passive Congestion (Prussion Blue Stain) - Lung

100. Perivascular and Peribronchial Lymphoid Aggregates - Lung

101. Pulmonary Atelectasis Adjacent to Normal Lung

102. Pulmonary Alveolar Macrophage Accumulations

103. Mycoplasma pulmonis Infection - Lungs

104. Chronic Sendai Virus Infection - Lungs

105. Pulmonary Alveolar Cell Adenoma

106. Pulmonary Alveolar Cell Adenoma

107. Adenoma - Pulmonary Surfactant Apoprotein - Lung

108. Papillary Adenocarcinoma - Lung

109. Lymph Node Metastasis of Pulmonary Adenocarcinoma - Lung

110. Electron Micrograph - Pulmonary Alveolar Type II Adenoma

111. Electron Micrograph - Pulmonary Alveolar Type II Adenoma

112. Electron Micrograph - Papillary Adenocarcinoma - Lung

113. Electron Micrograph - Papillary Adenocarcinoma - Lung

114. X-Zone - Adrenal Cortex

115. Adrenocortical Vacuolization (X-Zone)

116. Accessory Adrenocortical Nodule

117. Subcapsular Adrenocortical Spindle Cell Hyperplasia

118. Ceroid Pigment - Macrophages - Zona reticularis - Adrenal (H & E)

119. Ceroid Pigment - Adrenal (PAS)

120. Adrenocortical Adenoma (Type A Spindle Cell)

121. Adrenocortical Adenoma (Type B Solid Cell)

122. Electron Micrograph (TEM) - Adrenal Cortical Epithelial Cells

123. Electron Micrograph (TEM) - Adrenal Medullary Epithelial Cells

124. Electron Micrograph - Ceroid Pigment - Adrenal

125. Electron Micrograph - Ceroid Pigment - Adrenal

126. Adrenocortical Carcinoma (Type A Cell)

127. Adrenocortical Carcinoma (Type B Cell)

128. Pulmonary Metastasis - Adrenocortical Carcinoma (Type B Cell)

129. Diffuse Adrenal Medullary Hyperplasia

130. Pheochromocytoma

131. Pulmonary Metastasis - Pheochromocytoma

132. Ganglioneuroma - Adrenal

133. Ganglioneuroma - Adrenal

134. Electron Micrograph - Adrenocortical Type A Carcinoma (Lipid Droplets)

135. Electron Micrograph - Adrenocortical Type A Carcinoma (Desmosome)

136. Pituitary Cyst

137. Cystoid Degeneration - Pituitary

138. Cystoid Degeneration - Pituitary

139. Focal Hyperplasia - Pituitary

140. Focal Hyperplasia - Pituitary

141. Pituitary Adenoma

142. Pituitary Adenoma - Prolactin

143. Pituitary Carcinoma Invading Brain

144. Electron Micrograph - Pituitary Cystoid Degeneration

145. Electron Micrograph of Pituitary Cystoid Degeneration

146. Ectopic Thyroid at Base of Heart

147. Calcium Oxalate Crystals - Thyroid (Bright Field)

148. Calcium Oxalate Crystals - Thyroid (Bright Field and Dark Field)

149. Focal Thyroid Follicular Hyperplasia

150. Thyroid Papillary Adenoma

151. Thyroid Follicular Adenoma

152. Thyroid Solid Carcinoma

153. Thyroid Papillary/Follicular Carcinoma

154. Thyroid Papillary/Follicular Carcinoma

155. Thyroid Medullary (C-Cell) Carcinoma

156. Thyroid Medullary (C-Cell) Carcinoma

157. Thyroid Medullary (C-Cell) Carcinoma - Calcitonin (Immunoperoxidase)

158. Ectopic Parathyroid in the Thymus

159. Parathyroid Cyst

160. Bilateral Parathyroid Hyperplasia

161. Parathyroid Adenoma

162. Electron Micrograph - Normal C-Cells

163. Electron Micrograph - Normal C-Cells

164. Electron Micrograph - Medullary (C-Cell) Carcinoma

165. Electron Micrograph - Medullary (C-Cell) Carcinoma

166. Testicular Atrophy (Focal)

167. Testicular Atrophy (Diffuse)

168. Testicular Mineralization

169. Hyperplasia of Testicular Interstitial Cells

170. Testicular Interstitial Cell Carcinoma

171. Testicular Interstitial Cell Carcinoma

172. Pulmonary Metastasis - Interstitial Cell Carcinoma

173. Spermatocele - Epididymus

174. Preputial Gland Ectasia

175. Prostatic Adenocarcinoma

176. Prostatic Adenocarcinoma

177. Adenoma - Coagulating Gland

178. Adenoma - Coagulating Gland

179. Adenocarcinoma - Coagulating Gland

180. Adenocarcinoma - Coagulating Gland

181. Squamous Cell Carcinoma - Preputial Gland

182. Proestrus

183. Estrus

184. Metestrus

185. Diestrus

186. Adenosis - Vagina

187. Basal Cell Hyperplasia - Vagina

188. Granular Cell Tumor - Vagina

189. Squamous Cell Carcinoma - Vagina

190. Hydrometra - Uterus

191. Cystic Endometrial Hyperplasia

192. Adenomyosis - Uterus

193. Prolapse - Uterus

194. Leiomyoma - Uterus

195. Leiomyoma - Uterus

196. Leiomyosarcoma - Uterus

197. Endometrial Stromal Polyp

198. Endometrial Stromal Polyp

199. Endometrial Stromal Cell Sarcoma

200. Endometrial Stromal Cell Sarcoma

201. Mesothelioma - Uterus

202. Mesothelioma - Glandular Pattern - Uterus

203. Uterine Mesothelioma - Metastasis - Cervical Lymph Node

204. Adenocarcinoma - Uterus

205. Pulmonary Metastasis - Uterine Adenocarcinoma

206. Mild Multifocal Hyperplasia - Mammary Gland

207. Hyperplastic Alveolar Nodule (HAN) - Mammary Gland

208. Mammary Adenocarcinoma Type A

209. Mammary Adenocarcinoma Type B

210. Mammary Adenocarcinoma Type C

211. Mammary Adenoacanthoma (Adenosquamous Carcinoma)

212. Mammary Carcinosarcoma

213. Pulmonary Metastasis - Mammary Adenocarcinoma Type B

214. Normal Ovary

215. Ovarian Atrophy

216. Ovarian Cysts

217. Angiectasis - Ovary

218. Ectopic Pregnancy - Ovary

219. Fibrosis - Oviduct

220. Hyaline Change - Oviduct

221. Vacuolization - Oviduct

222. Electron Micrograph of Oviduct Hyaline Change

223. Electron Micrograph of Oviduct Vacuolization

224. Tubular Adenoma (Tubular Mesothelioma) - Ovary

225. Tubular Adenoma - Ovary

226. Tubular Carcinoma - Ovary

227. Serous Cystadenoma - Ovary

228. Dysgerminoma - Ovary

229. Teratoma - Ovary

230. Teratoma - Ovary

231. Granulosa Cell Tumor - Ovary

232. Cal-Exner Body - Ovarian Granulosa Cell Tumor

233. Pulmonary Metastasis - Ovarian Granulosa Cell Tumor

234. Thecoma - Ovary

235. Luteinized Thecoma - Ovary

236. Luteoma - Ovary

237. Sertoli Cell Tumor - Ovary

238. Hemangioma - Ovary

239. Hemangiosarcoma - Ovary

240. Flattened Bowman's Parietal Epithelium - Female Mouse

241. Cuboidal Bowman's Parietal Epithelium - Male Mouse

242. Double Pelvis

243. Infarct - Kidney

244. Papillary Necrosis - Kidney

245. Hydronephrosis

246. Polycystic Kidney

247. Chronic Renal Disease (Nephropathy)

248. Membrano-proliferative Glomerulonephritis

249. Glomerulonephritis - Murine Lupus Erythematosus

250. Glomerular Amyloidosis

251. Glomerular Amyloidosis (Thioflavin T Stain)

252. Calculi - Kidney Pelvis

253. Tubular Cell Adenoma - Kidney

254. Tubular Cell Carcinoma - Kidney

255. Pulmonary Metastasis - Renal Tubular Cell Carcinoma

256. Ureteral Diverticulum

257. Normal Bladder Urothelium

258. Refractile Spherules (Bright Field) - Urinary Bladder

259. Refractile Spherules (Dark Field) - Urinary Bladder

260. Calculi and Chronic Cystitis - Urinary Bladder

261. Lymphoid Aggregate - Urinary Bladder

262. Simple Hyperplasia - Urinary Bladder

263. Nodular Hyperplasia - Urinary Bladder

264. Electron Micrograph - Normal Urothelium (SEM)

265. Electron Micrograph - Normal Urothelium (TEM)

266. Electron Micrograph - Urothelial Hyperplasia (TEM)

267. Electron Micrograph - Urothelial Hyperplasia (SEM)

268. Papilloma (Pedunculated) - Urinary Bladder

269. Papilloma (sessile) - Urinary Bladder

270. Transitional Cell Carcinoma - Urinary Bladder

271. Transitional Cell Carcinoma with Squamous Metaplasia - Urinary Bladder

272. Pulmonary Metastasis - Urinary Bladder, Transitional Cell Carcinoma

273. Undifferentiated Carcinoma - Urinary Bladder

274. Hemangioma - Urinary Bladder

275. Hemangiosarcoma - Urinary Bladder

276. Cysts - Thymus

277. Atrophy - Thymus

278. Ectopic Thymus - Parathyroid

279. Accessory Spleen - Pancreas

280. Amyloidosis - Spleen

281. Hemosiderosis - Spleen

282. Melanosis - Spleen

283. Follicular Hyperplasia - Spleen

284. Erythrocytic Hyperplasia - Spleen

285. Granulocytic Hyperplasia - Spleen

286. Megakaryocytosis - Spleen

287. Atrophy - Bone Marrow

288. Sinus Histiocytosis - Lymph Node

289. Lymphoid Follicular Hyperplasia - Lymph Node

290. Plasmacytosis - Lymph Node

291. Plasmacytosis - Lymph Node (Immunoperoxidase for IgG)

292. Lymphoblastic Lymphoma - Liver

293. Lymphoblastic Lymphoma - Thymus

294. Leukemia - Lymphoblastic Lymphoma

295. Follicular Center Cell Lymphoma - Spleen

296. Follicular Center Cell Lyphoma - Spleen (Immunoperoxidase for IgG)

297. Follicular Center Cell Lymphoma - Lymph Node

298. Plasma Cell Lymphoma - Liver

299. Immunoblastic Lymphoma

300. Immunoblastic Lymphoma - Cytoplasmic Immunoglobulin

301. Thymoma - Epithelial Component

302. Histiocytic Sarcoma - Liver

303. Histiocytic Sarcoma - Liver (Alpha 1-Antitrypsin)

304. Histiocytic Sarcoma - Uterus

305. Mast Cell Tumor - Kidney (H & E)

306. Mast Cell Tumor - Kidney (Toluidine Blue)

307. Granulocytic Leukemia - Liver

308. Electron Micrograph - Histiocytic Sarcoma (TEM)

309. Electron Micrograph - Histiocytic Sarcoma (TEM)

310. Mites - Skin

311. Squamous Cell Papilloma - Skin

312. Basal Cell Carcinoma - Skin

313. Squamous Cell Carcinoma Arising in a Papilloma - Skin

314. Squamous Cell Carcinoma - Keratin

315. Sebaceous Gland Adenoma - Skin

316. Spindle Cell Sarcoma - Subcutis

317. Hemangiopericytoma - Subcutis

318. Electron Micrograph - Fibrosarcoma - Collagen Production

319. Electron Micrograph - Fibrosarcoma - Collagen Production

320. Early Fibro-osseus Lesion - Bone

321. Advanced Fibro-osseus Lesion - Bone

322. Osseous Metaplasia - Kidney

323. Osteosarcoma

324. Osteosarcoma

325. Hepatic Metastasis - Osteosarcoma

326. Chondrosarcoma

327. Rhabdomyosarcoma - Skeletal Muscle

328. Cerebral Calcification - Thalamus

329. Inclusion Cyst - Spinal Cord

330. Inclusion Cyst - Brain

331. Hydrocephalus - Lateral Ventricle

332. Lipid Storage Disease - Decrease in Purkinje Cells - Cerebellum

333. Lipid Storage Disease - Cerebrum

334. Vacuolization of White Matter - Brain

335. Cerebral Infarct

336. Electron Micrograph - Cerebral Thalamic Calcification

337. Electron Micrograph - Cerebral Thalamic Calcification

338. X-Ray Microanalysis - Cerebral Calcification

339. Oligodenroglioma - Brain

340. Astrocytoma - Brain

341. Lipoma - Brain

342. Lipoma - Brain

343. Choroid Plexus Tumor - Brain

344. Myxomatous Meningioma - Brain

345. Primary Hemangiosarcoma - Brain

346. Teratoma - Brain

347. Ectopic Harderian Gland in Extraorbital Lacrimal Gland

348. Ectasia - Harderian Gland

349. Adenoma - Harderian Gland

350. Adenocarcinoma - Harderian Gland

351. Pulmonary Metastasis - Harderian Gland Adenocarcinoma

352. Cataract

353. Normal Retina

354. Retinal Atrophy

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